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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-4-14
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pubmed:abstractText |
Pyrrolobenzodiazepine-diethylphosphonate conjugates have been designed and synthesized that link through two different types of spacers that are simple alkane chain and also a piperazine moiety side-armed with the alkane chains. These pyrrolobenzodiazepine conjugates have exhibited remarkable DNA-binding affinity and improved solubility in water, a representative compound 7d showing promising in vitro cytotoxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
3895-906
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18262426-Amination,
pubmed-meshheading:18262426-Animals,
pubmed-meshheading:18262426-Benzodiazepines,
pubmed-meshheading:18262426-Cattle,
pubmed-meshheading:18262426-Cell Line, Tumor,
pubmed-meshheading:18262426-Cell Survival,
pubmed-meshheading:18262426-DNA,
pubmed-meshheading:18262426-Dimerization,
pubmed-meshheading:18262426-Humans,
pubmed-meshheading:18262426-Molecular Structure,
pubmed-meshheading:18262426-Nucleic Acid Denaturation,
pubmed-meshheading:18262426-Phosphonic Acids,
pubmed-meshheading:18262426-Pyrroles,
pubmed-meshheading:18262426-Structure-Activity Relationship,
pubmed-meshheading:18262426-Temperature
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pubmed:year |
2008
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pubmed:articleTitle |
Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
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pubmed:affiliation |
Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh 500 007, India. ahmedkamal@iict.res.in
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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