Linked Life Data

1825865

Source:http://linkedlifedata.com/resource/pubmed/id/1825865

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-4-18
pubmed:abstractText
Second-trimester sonographic measurement of nuchal skinfold thickness has been proposed as a potential screening tool for Down syndrome detection. The feasibility of this technique was tested in a prospective study of 3338 consecutive pregnancies at 14-21 weeks' gestation. A nuchal skinfold thickness of 6 mm or greater was identified in 47 fetuses (1.4%), 12 of whom proved subsequently by either amniocentesis or postnatal follow-up to have Down syndrome. The sensitivity of nuchal skinfold thickness for Down syndrome detection was 75% (12 of 16 cases). When adjusted for the incidence of Down syndrome in the general population (one in 710 births), the positive predictive value of nuchal skinfold thickness for Down syndrome detection was one in 13. The observed sensitivity, false-positive rate, and predictive value suggest that amniocentesis should be offered when a nuchal skinfold thickness of 6 mm or greater is observed between 14-21 weeks' gestation.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0029-7844
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-6
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Sonographically measured nuchal skinfold thickness as a screening tool for Down syndrome: results of a prospective clinical trial.
pubmed:affiliation
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't