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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-4-8
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pubmed:abstractText |
Phosphoprotein driven cellular signaling events represent most of the new molecular targets for cancer treatment. Application of reverse-phase protein microarray technology for the study of ongoing signaling activity within breast tumor specimens holds great potential for elucidating and profiling signaling activity in real-time for patient-tailored therapy. Analysis of laser capture microdissection primary human breast tumors and metastatic lesions reveals pathway specific profiles and a new way to classify cancer based on functional signaling portraits. Moreover, the data demonstrate the requirement of laser capture microdissection for analysis and reveal the metastasis-specific changes that occur within a new microenvironment. Analysis of biopsy material from clinical trials for targeted therapeutics demonstrates the feasibility and utility of comprehensive signal pathway activation profiling for molecular analysis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1535-3893
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pubmed:author |
pubmed-author:BellucoClaudioC,
pubmed-author:DengJianghongJ,
pubmed-author:EspinaVirginiaV,
pubmed-author:EssermanLaura JLJ,
pubmed-author:LairdJulieJ,
pubmed-author:LiottaLance ALA,
pubmed-author:MammanoEnzoE,
pubmed-author:NittiDonatoD,
pubmed-author:PetricoinEmanuel FEF3rd,
pubmed-author:PierobonMariaelenaM,
pubmed-author:SpeerRunaR,
pubmed-author:SwainSandra MSM,
pubmed-author:WulfkuhleJulia DJD,
pubmed-author:YangSherry XSX
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1508-17
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18257519-Breast Neoplasms,
pubmed-meshheading:18257519-Cluster Analysis,
pubmed-meshheading:18257519-Female,
pubmed-meshheading:18257519-Humans,
pubmed-meshheading:18257519-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18257519-Lasers,
pubmed-meshheading:18257519-Liver Neoplasms,
pubmed-meshheading:18257519-Microdissection,
pubmed-meshheading:18257519-Phosphoproteins,
pubmed-meshheading:18257519-Phosphorylation,
pubmed-meshheading:18257519-Protein Kinase Inhibitors,
pubmed-meshheading:18257519-Protein Kinases,
pubmed-meshheading:18257519-Proteomics,
pubmed-meshheading:18257519-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18257519-Quinazolines,
pubmed-meshheading:18257519-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:18257519-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy.
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pubmed:affiliation |
Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, USA. jwulfkuh@gmu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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