Linked Life Data

1825477

Source:http://linkedlifedata.com/resource/pubmed/id/1825477

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-4-2
pubmed:abstractText
Epiglycanin (Epi) is a mucin-like glycoprotein carrying multiple Thomsen Freidenreich (TF) and Tn determinants secreted by a murine mammary adenocarcinoma, TA3-Ha. As an attempt to further characterize immunoregulatory networks in the TA3-Ha animal model, we tested whether Epi causes active suppression of the cell-mediated immune response against TF determinants. In this study, we show that (a) s.c. injection of epiglycanin emulsified in either complete Freund's adjuvant or Ribi adjuvant containing trehalose dimycolate and monophosphoryl lipid A elicits a classical specific delayed-type hyperactivity response to TF haptens either naturally expressed on epiglycanin or as synthetic haptens conjugated to a protein carrier; (b) i.v. injection of as little as 500 ng of Epi induces specific immunosuppression to anti-Epi and anti-TF synthetic antigen delayed-type hyperactivity responses; (c) this immunosuppression can be abrogated by i.v. injection of cyclophosphamide prior to immunizations; (d) Epi-induced specific immunosuppression can be adoptively transferred by nylon wool-nonadherent cells 6 days following i.v. injection of Epi; (e) pretreatment of suppressor cell populations with anti-Thy-1, anti-L3T4, anti-Lyt-1, or anti-I-Jk but not anti-Lyt-2 monoclonal antibodies plus complement prior to adoptive transfer abolished immunosuppression; (f) i.v. injection of immunosuppressive amounts of Epi on Days 2 and 6 after transplantation of TA3-Ha cells increased the lethality of the tumor transplant. These results suggest that Epi-induced specific immunosuppression in the TA3-Ha animal model is mediated by Thy-1+, L3T4+, Lyt-1+2-, and I-Jk+ suppressor cells. The results are also consistent with the suggestion that this immunosuppression may enhance TA3-Ha tumor growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1170-6
pubmed:dateRevised
2007-12-5
pubmed:meshHeading
pubmed-meshheading:1825477-Adenocarcinoma, pubmed-meshheading:1825477-Animals, pubmed-meshheading:1825477-Antigens, Neoplasm, pubmed-meshheading:1825477-Antigens, Tumor-Associated, Carbohydrate, pubmed-meshheading:1825477-Cyclophosphamide, pubmed-meshheading:1825477-Disaccharides, pubmed-meshheading:1825477-Dose-Response Relationship, Drug, pubmed-meshheading:1825477-Female, pubmed-meshheading:1825477-Hypersensitivity, Delayed, pubmed-meshheading:1825477-Immunosuppression, pubmed-meshheading:1825477-Immunotherapy, pubmed-meshheading:1825477-Injections, Intravenous, pubmed-meshheading:1825477-Mammary Neoplasms, Experimental, pubmed-meshheading:1825477-Membrane Glycoproteins, pubmed-meshheading:1825477-Mice, pubmed-meshheading:1825477-Mice, Inbred Strains, pubmed-meshheading:1825477-Neoplasm Proteins, pubmed-meshheading:1825477-T-Lymphocytes, Regulatory
pubmed:year
1991
pubmed:articleTitle
Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-HA).
pubmed:affiliation
Department of Immunology, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't