Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-5-20
pubmed:abstractText
Drug-eluting stents are widely used to prevent restenosis but are associated with late endothelial damage. To understand the basis for this effect, we have studied the consequences of a prolonged incubation with rapamycin on the viability and functions of endothelial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cardiovascular Agents, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3, http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin, http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase, http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RICTOR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/RPTOR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 70-kDa, http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus, http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus, http://linkedlifedata.com/resource/pubmed/chemical/Theophylline, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/bamifylline, http://linkedlifedata.com/resource/pubmed/chemical/mTORC1 complex, human
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0008-6363
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
563-71
pubmed:dateRevised
2010-12-13
pubmed:meshHeading
pubmed-meshheading:18250144-Adaptor Proteins, Signal Transducing, pubmed-meshheading:18250144-Apoptosis, pubmed-meshheading:18250144-Blotting, Western, pubmed-meshheading:18250144-Cardiovascular Agents, pubmed-meshheading:18250144-Carrier Proteins, pubmed-meshheading:18250144-Caspase 3, pubmed-meshheading:18250144-Cell Movement, pubmed-meshheading:18250144-Cell Survival, pubmed-meshheading:18250144-Dose-Response Relationship, Drug, pubmed-meshheading:18250144-E-Selectin, pubmed-meshheading:18250144-Endothelial Cells, pubmed-meshheading:18250144-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:18250144-Humans, pubmed-meshheading:18250144-Immunoprecipitation, pubmed-meshheading:18250144-L-Lactate Dehydrogenase, pubmed-meshheading:18250144-Microscopy, Confocal, pubmed-meshheading:18250144-Necrosis, pubmed-meshheading:18250144-Nitric Oxide, pubmed-meshheading:18250144-Nitric Oxide Synthase Type III, pubmed-meshheading:18250144-Polymerase Chain Reaction, pubmed-meshheading:18250144-Protein Kinases, pubmed-meshheading:18250144-Proteins, pubmed-meshheading:18250144-Ribosomal Protein S6 Kinases, 70-kDa, pubmed-meshheading:18250144-Sirolimus, pubmed-meshheading:18250144-Stress Fibers, pubmed-meshheading:18250144-TOR Serine-Threonine Kinases, pubmed-meshheading:18250144-Tacrolimus, pubmed-meshheading:18250144-Theophylline, pubmed-meshheading:18250144-Time Factors, pubmed-meshheading:18250144-Transcription Factors, pubmed-meshheading:18250144-Tumor Necrosis Factor-alpha, pubmed-meshheading:18250144-Up-Regulation
pubmed:year
2008
pubmed:articleTitle
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.
pubmed:affiliation
Department of Experimental Medicine, Unit of General and Clinical Pathology, University of Parma, Via Volturno 39, 43100 Parma, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't