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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-8-27
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pubmed:abstractText |
Urokinase (uPA) and its receptor (uPAR) play an important role in tumor growth and metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. In this study, ATF-Fc, an antibody-like molecule comprising the amino-terminal fragment of human uPA (ATF) linked to the Fc fragment of human IgG1 via a flexible linker was developed. Its antitumor activities were evaluated in vitro and in vivo. The results showed that ATF-Fc had obvious cytotoxic effect on several types of tumor cells, which is dependent on cellular expression of uPAR and its Fc fragment. Treatment with ATF-Fc caused a significant suppression on tumor growth and metastasis of xenograft human tumors (MCF-7 breast cancer and BGC-823 gastric cancer) in athymic nude mice. Furthermore, we demonstrated that ATF-Fc had an anti-angiogenesis activity both in vitro and in vivo. In conclusion, we provided a novel therapeutic antibody-like molecule in the management of a variety of solid tumors by disrupting the uPA/uPAR interaction.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fc Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/PLAUR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Plaur protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Urokinase Plasminogen...,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1555-8576
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pubmed:author |
pubmed-author:ChenHui-PengHP,
pubmed-author:DuanHai-FengHF,
pubmed-author:GaoLi-HuaLH,
pubmed-author:HuXian-WenXW,
pubmed-author:LiJin-FengJF,
pubmed-author:LiYong-MeiYM,
pubmed-author:LiangYinY,
pubmed-author:PanShu-YuanSY,
pubmed-author:WuChu-TseCT,
pubmed-author:XiYongyiY,
pubmed-author:ZhaoSu-RongSR
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18245952-Amino Acid Sequence,
pubmed-meshheading:18245952-Animals,
pubmed-meshheading:18245952-Antibodies,
pubmed-meshheading:18245952-Cell Line, Tumor,
pubmed-meshheading:18245952-Extracellular Matrix,
pubmed-meshheading:18245952-Humans,
pubmed-meshheading:18245952-Immunoglobulin Fc Fragments,
pubmed-meshheading:18245952-Immunoglobulin G,
pubmed-meshheading:18245952-Mice,
pubmed-meshheading:18245952-Mice, Nude,
pubmed-meshheading:18245952-Molecular Sequence Data,
pubmed-meshheading:18245952-Neoplasm Metastasis,
pubmed-meshheading:18245952-Neoplasms,
pubmed-meshheading:18245952-Neovascularization, Pathologic,
pubmed-meshheading:18245952-Receptors, Cell Surface,
pubmed-meshheading:18245952-Receptors, Urokinase Plasminogen Activator,
pubmed-meshheading:18245952-Urokinase-Type Plasminogen Activator
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of tumor growth and metastasis by ATF-Fc, an engineered antibody targeting urokinase receptor.
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pubmed:affiliation |
Beijing Institute of Biotechnology (BIB), Fengtai District, Beijing, China. hu.xianwen@tsinghua.org.cn
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pubmed:publicationType |
Journal Article
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