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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-4
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pubmed:abstractText |
To determine the safety, dose-limiting toxicity, maximum tolerated dose, and pharmacokinetic and pharmacodynamic profiles of the novel hydroxamate histone deacetylase inhibitor belinostat (previously named PXD101) in patients with advanced refractory solid tumors.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BrownRobertR,
pubmed-author:Buhl-JensenPeterP,
pubmed-author:DeBonoJohann SJS,
pubmed-author:EvansT R JeffryTR,
pubmed-author:KnoblauchPoulP,
pubmed-author:OoiChean EngCE,
pubmed-author:PlumbJane AJA,
pubmed-author:RasmussenAnnieA,
pubmed-author:SteeleNicola LNL,
pubmed-author:TjørnelundJetteJ,
pubmed-author:VidalLauraL
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
804-10
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18245542-Adult,
pubmed-meshheading:18245542-Aged,
pubmed-meshheading:18245542-Antineoplastic Agents,
pubmed-meshheading:18245542-Drug Administration Schedule,
pubmed-meshheading:18245542-Enzyme Inhibitors,
pubmed-meshheading:18245542-Female,
pubmed-meshheading:18245542-Histone Deacetylase Inhibitors,
pubmed-meshheading:18245542-Histone Deacetylases,
pubmed-meshheading:18245542-Humans,
pubmed-meshheading:18245542-Hydroxamic Acids,
pubmed-meshheading:18245542-Infusions, Intravenous,
pubmed-meshheading:18245542-Life Expectancy,
pubmed-meshheading:18245542-Male,
pubmed-meshheading:18245542-Middle Aged,
pubmed-meshheading:18245542-Neoplasms,
pubmed-meshheading:18245542-Patient Selection
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pubmed:year |
2008
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pubmed:articleTitle |
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors.
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pubmed:affiliation |
The Beatson West of Scotland Cancer Centre, Glasgow, UK. nicola.steele@northglasgow.scot.nhs.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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