Source:http://linkedlifedata.com/resource/pubmed/id/18243758
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-3-13
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| pubmed:abstractText |
We investigated mRNA expressions of interleukin 10 (IL-10) during fracture healing for wound age determination. Macroscopically, calluses were formed at 144 h post-injury, and thickening of the fracture edge was observed at 240 h post-injury. Slight infiltration of neutrophils and macrophages was detected at 3 h post-injury, and moderate infiltration of T and B lymphocytes was detected at 72 h post-injury. In addition, osteoblasts proliferated at 24 h post-injury. IL-10 mRNA increased immediately after the intervention and peaked at 24 h, and the expressions were detected in osteocytes before and after injury, and in osteoblasts at 3 h post-injury. Although the intensity was stable in osteocytes, that in osteoblasts was strongest at 24 h post-injury. Among inflammatory cells, the expressions were exclusively detected in macrophages. These results indicated that examinations of macroscopic and microscopic changes in fracture edges, and mRNA expressions of IL-10, would be informative for fracture healing and dating.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1344-6223
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
131-7
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| pubmed:meshHeading |
pubmed-meshheading:18243758-Animals,
pubmed-meshheading:18243758-B-Lymphocytes,
pubmed-meshheading:18243758-Cell Proliferation,
pubmed-meshheading:18243758-Forensic Pathology,
pubmed-meshheading:18243758-Fracture Healing,
pubmed-meshheading:18243758-Fractures, Bone,
pubmed-meshheading:18243758-Immunohistochemistry,
pubmed-meshheading:18243758-In Situ Hybridization,
pubmed-meshheading:18243758-Interleukin-10,
pubmed-meshheading:18243758-Macrophages,
pubmed-meshheading:18243758-Mice,
pubmed-meshheading:18243758-Mice, Inbred BALB C,
pubmed-meshheading:18243758-Models, Animal,
pubmed-meshheading:18243758-Neutrophils,
pubmed-meshheading:18243758-Osteoblasts,
pubmed-meshheading:18243758-Polymerase Chain Reaction,
pubmed-meshheading:18243758-RNA, Messenger,
pubmed-meshheading:18243758-T-Lymphocytes,
pubmed-meshheading:18243758-Time Factors
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
A study on mRNA expressions of interleukin 10 during fracture healing for wound age determination.
|
| pubmed:affiliation |
Department of Legal Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan. mtakamiy@iwate-med.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|