| pubmed-article:18242184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:18242184 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18242184 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18242184 | pubmed:dateCreated | 2008-2-26 | lld:pubmed |
| pubmed-article:18242184 | pubmed:abstractText | beta-Catenin/Tcf and NF-kappaB pathways play an important role in biological functions. We determined the underlying mechanisms of differential interaction between two pathways in various human cancer cell lines. NF-kappaB positively regulated beta-catenin/Tcf pathways in human glioblastoma, whereas it has an opposite effect on beta-catenin/Tcf pathways in colon, liver, and breast cancer cells. Expression of lucine zipper tumor suppressor 2 (lzts2) was positively regulated by NF-kappaB activity in colon, liver, and breast cancer cells, whereas negatively regulated in glioma cells. Downregulation of lzts2 increased the beta-catenin/Tcf promoter activity and inhibited NF-kappaB-induced modulation of the nuclear translocation of beta-catenin. These data indicate that the differential crosstalk between beta-catenin/Tcf and NF-kappaB pathway in various cancer cells is resulted from the differences in the regulation of NF-kappaB-induced lzts2 expression. | lld:pubmed |
| pubmed-article:18242184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18242184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18242184 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18242184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18242184 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18242184 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:JungJin SupJS | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:YuSung SookSS | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:KimDong... | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:ChoHyun HwaHH | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:YuJi MinJM | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:SongJi SunJS | lld:pubmed |
| pubmed-article:18242184 | pubmed:author | pubmed-author:ChoiSung... | lld:pubmed |
| pubmed-article:18242184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18242184 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:18242184 | pubmed:volume | 582 | lld:pubmed |
| pubmed-article:18242184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18242184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18242184 | pubmed:pagination | 616-22 | lld:pubmed |
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| pubmed-article:18242184 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18242184 | pubmed:articleTitle | Differential effect of NF-kappaB activity on beta-catenin/Tcf pathway in various cancer cells. | lld:pubmed |
| pubmed-article:18242184 | pubmed:affiliation | Department of Physiology, School of Medicine, Pusan National University, Suh-Gu, Pusan, Republic of Korea. | lld:pubmed |
| pubmed-article:18242184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18242184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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