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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-2-26
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pubmed:abstractText |
beta-Catenin/Tcf and NF-kappaB pathways play an important role in biological functions. We determined the underlying mechanisms of differential interaction between two pathways in various human cancer cell lines. NF-kappaB positively regulated beta-catenin/Tcf pathways in human glioblastoma, whereas it has an opposite effect on beta-catenin/Tcf pathways in colon, liver, and breast cancer cells. Expression of lucine zipper tumor suppressor 2 (lzts2) was positively regulated by NF-kappaB activity in colon, liver, and breast cancer cells, whereas negatively regulated in glioma cells. Downregulation of lzts2 increased the beta-catenin/Tcf promoter activity and inhibited NF-kappaB-induced modulation of the nuclear translocation of beta-catenin. These data indicate that the differential crosstalk between beta-catenin/Tcf and NF-kappaB pathway in various cancer cells is resulted from the differences in the regulation of NF-kappaB-induced lzts2 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
616-22
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pubmed:meshHeading |
pubmed-meshheading:18242184-Cell Cycle Proteins,
pubmed-meshheading:18242184-Cell Line, Tumor,
pubmed-meshheading:18242184-DNA-Binding Proteins,
pubmed-meshheading:18242184-Down-Regulation,
pubmed-meshheading:18242184-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18242184-Humans,
pubmed-meshheading:18242184-Models, Biological,
pubmed-meshheading:18242184-NF-kappa B,
pubmed-meshheading:18242184-Neoplasms,
pubmed-meshheading:18242184-Peptides,
pubmed-meshheading:18242184-Signal Transduction,
pubmed-meshheading:18242184-TCF Transcription Factors,
pubmed-meshheading:18242184-Tumor Suppressor Proteins,
pubmed-meshheading:18242184-beta Catenin
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pubmed:year |
2008
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pubmed:articleTitle |
Differential effect of NF-kappaB activity on beta-catenin/Tcf pathway in various cancer cells.
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pubmed:affiliation |
Department of Physiology, School of Medicine, Pusan National University, Suh-Gu, Pusan, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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