Linked Life Data

18241922

Source:http://linkedlifedata.com/resource/pubmed/id/18241922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-3-10
pubmed:abstractText
The Atlantic salmon (Salmo salar) T-cell receptor gamma (TCRgamma) gene has extensive diversity in its capacity for antigen recognition due to the V-J-C gene segments recombinational possibilities, and N-region diversity. This is the first report completely characterizing and annotating a TCRgamma gene locus in teleosts. We identified two different TCRgamma loci in Atlantic salmon. The first locus, TCRgamma 1, spans 260 kbp and contains four tandemly repeated clusters each of which consists of 1-4 variable (V) segments, 1-2 sets of a joining (J) segment and a constant (C) region. In total, 10 V segments, 5 J segments and 5 C regions were found in locus 1. In the second locus, TCRgamma 2, a single non-expressed V-J-C cluster was found. Surprisingly, the Atlantic salmon TCRgamma loci have a larger number of C regions relative to other teleosts, mouse and human. In addition, each Atlantic salmon TCRgamma C region has a different connecting peptide region that may result in distinct cellular responses. Expression data confirm the diverse repertoire found at the genomic level. At least 6 out of 7 functional V segments, all 5 J segments and all 5 C regions found in TCRgamma 1 were identified in TCRgamma transcription analysis. The identification and characterization of the functional TCRgamma 1 along with the associated TCR alpha/delta locus suggest that Atlantic salmon have a functional gammadelta T-cell immune component.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0161-5890
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2150-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Functional adaptive diversity of the Atlantic salmon T-cell receptor gamma locus.
pubmed:affiliation
Centre for Biomedical Research, University of Victoria, PO Box 3020 STN CSC, Victoria, British Columbia, V8W 3N5 Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't