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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-2-4
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pubmed:abstractText |
Vitamin K epoxide reductase (VKORC1) is the drug target for inhibition by coumarin-based anticoagulant drugs such as warfarin. Warfarin therapy has been reported as a leading cause of drug-related hospitalization and there is therefore an urgent need to develop tests for better warfarin prescription. We report here the distribution of the intron 1 -136 T>C (1173 T>C intron) polymorphism of VKORC1, previously reported to be associated with warfarin maintenance dose in Caucasians and Japanese, in several ethnic populations from Japan and Israel, and describe its significance for warfarin dosage in Japanese cardiovascular surgery patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1744-8042
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pubmed:author |
pubmed-author:FujiokaTomoakiT,
pubmed-author:FukuhiroYoshiakiY,
pubmed-author:FukushimaNorikoN,
pubmed-author:GurwitzDavidD,
pubmed-author:HabanoWataruW,
pubmed-author:NakaiKeikoK,
pubmed-author:NakaiKenjiK,
pubmed-author:ObaraWataruW,
pubmed-author:OkaTakanoriT,
pubmed-author:OkabayashiHitoshiH,
pubmed-author:SuwabeAkiraA,
pubmed-author:TsuboiJyunichiJ
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
713-9
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pubmed:meshHeading |
pubmed-meshheading:18240904-Anticoagulants,
pubmed-meshheading:18240904-Asian Continental Ancestry Group,
pubmed-meshheading:18240904-Cardiovascular Diseases,
pubmed-meshheading:18240904-Cardiovascular Surgical Procedures,
pubmed-meshheading:18240904-Dose-Response Relationship, Drug,
pubmed-meshheading:18240904-Ethnic Groups,
pubmed-meshheading:18240904-Genotype,
pubmed-meshheading:18240904-Humans,
pubmed-meshheading:18240904-Introns,
pubmed-meshheading:18240904-Japan,
pubmed-meshheading:18240904-Jews,
pubmed-meshheading:18240904-Mixed Function Oxygenases,
pubmed-meshheading:18240904-Polymorphism, Genetic,
pubmed-meshheading:18240904-Polymorphism, Single Nucleotide,
pubmed-meshheading:18240904-Warfarin
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pubmed:year |
2007
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pubmed:articleTitle |
Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients.
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pubmed:affiliation |
Iwate Medical University, Department of Laboratory Medicine, Morioka 020-8505, Japan. knakai@iwate-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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