Linked Life Data

18235230

Source:http://linkedlifedata.com/resource/pubmed/id/18235230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-21
pubmed:abstractText
Low dose radiotherapy is an effective palliative treatment for follicular lymphoma, inducing the rapid apoptosis of the neoplastic B cells. Comparison of the gene expression profiles of follicular lymphoma biopsy samples taken before and after radiation shows that the intact p53 pathway is the driving force to the apoptotic process. Death of the Bcl-2 overexpressing B cells can be explained by the prominent induction of the extrinsic apoptotic pathway, with an active role of the neoplastic microenvironment for the expression of death receptor ligands and the clearance of the apoptotic cells. These insights have implications for the design of new protocols in the treatment of follicular lymphoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
436-9
pubmed:dateRevised
2008-9-23
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The role of the p53 pathway in the treatment of follicular lymphoma.
pubmed:affiliation
Experimental Medicine Unit, de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
pubmed:publicationType
Journal Article, Review