Linked Life Data

18232331

Source:http://linkedlifedata.com/resource/pubmed/id/18232331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-31
pubmed:abstractText
Moyamoya disease is characterized by progressive steno-occlusive changes at the terminal portions of the bilateral internal carotid arteries with arterial collateral vessels at the base of the brain. As the incidence of moyamoya disease is highest in Japanese and Asians, Japanese researchers have made enormous efforts to illuminate the pathogenesis, the epidemiology, the clinical features and the treatment of this disease for five decades. The disease was called variously according to each researcher's assumption of the pathogenesis in the early period. After presentation of the initial nationwide data summarized by Nishimoto, et al. at the Symposium Neuroradiologicum in Paris in 1967, the disease was named Nishimoto's disease in Europe. Since the publication in the English literature by Suzuki, et al. in 1969, the term "moyamoya disease" has been accepted in the international community. The etiology of moyamoya disease is still unknown. Genetic backgrounds have been suggested in familial moyamoya disease. Angiogenetic cytokines may play a role in progression of steno-occlusive changes and/or angiogenesis of collaterals. The patients with moyamoya disease present with a variety of clinical symptoms, such as ischemic deficits, intracranial hemorrhage, sensory disturbance, involuntary movement, seizures and headache. Ischemic symptoms dominate in children, though intracranial hemorrhage is more common in adults. The ischemic attacks in children are often provoked by hyperventilation. Intracranial hemorrhage is mainly caused by hemodynamic stress on fragile moyamoya vessels. Many surgical options, including indirect bypass, direct bypass and their combination, have been developed to increase cerebral blood flow for patients with ischemic problems. Ongoing studies may elucidate the pathogenesis of the disease and efficacy of bypass surgery for hemorrhagic cases.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1881-6096
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-42
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Moyamoya disease].
pubmed:affiliation
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
pubmed:publicationType
Journal Article, English Abstract, Review, Historical Article