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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0008976,
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0034656,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0279781,
umls-concept:C1514307,
umls-concept:C1522673,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-6
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pubmed:abstractText |
Several small studies have reported that having a high percentage of breast tumor cells that express the proliferation antigen Ki-67 (ie, a high Ki-67 labeling index) predicts better response to neoadjuvant chemotherapy. However, the predictive value of a high Ki-67 labeling index for response to adjuvant chemotherapy is unclear. To investigate whether Ki-67 labeling index predicts response to adjuvant chemoendocrine therapy, we assessed Ki-67 expression in tumor tissue from 1924 (70%) of 2732 patients who were enrolled in two randomized International Breast Cancer Study Group trials of adjuvant chemoendocrine therapy vs endocrine therapy alone for node-negative breast cancer. A high Ki-67 labeling index was associated with other factors that predict poor prognosis. Among the 1521 patients with endocrine-responsive tumors, a high Ki-67 labeling index was associated with worse disease-free survival but the Ki-67 labeling index did not predict the relative efficacy of chemoendocrine therapy compared with endocrine therapy alone. Thus, Ki-67 labeling index was an independent prognostic factor but was not predictive of better response to adjuvant chemotherapy in these studies.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2105
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pubmed:author |
pubmed-author:BrownR WRW,
pubmed-author:Castiglione-GertschMonicaM,
pubmed-author:CoatesAlan SAS,
pubmed-author:ColleoniMarcoM,
pubmed-author:GelberRichard DRD,
pubmed-author:GoldhirschAronA,
pubmed-author:GolouhRastkoR,
pubmed-author:GustersonBarry ABA,
pubmed-author:International Breast Cancer Study Group,
pubmed-author:KovácsAnikóA,
pubmed-author:MaffiniFaustoF,
pubmed-author:MaioranoEugenioE,
pubmed-author:MastropasquaMauro GMG,
pubmed-author:OhlschlegelChristianC,
pubmed-author:PerinTizianaT,
pubmed-author:PillayKomalaK,
pubmed-author:PriceKaren NKN,
pubmed-author:ReganMeredith MMM,
pubmed-author:VialeGiuseppeG
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
100
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
207-12
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pubmed:meshHeading |
pubmed-meshheading:18230798-Adult,
pubmed-meshheading:18230798-Aged,
pubmed-meshheading:18230798-Analysis of Variance,
pubmed-meshheading:18230798-Antineoplastic Agents, Hormonal,
pubmed-meshheading:18230798-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18230798-Breast Neoplasms,
pubmed-meshheading:18230798-Chemotherapy, Adjuvant,
pubmed-meshheading:18230798-Cyclophosphamide,
pubmed-meshheading:18230798-Female,
pubmed-meshheading:18230798-Fluorouracil,
pubmed-meshheading:18230798-Humans,
pubmed-meshheading:18230798-Ki-67 Antigen,
pubmed-meshheading:18230798-Logistic Models,
pubmed-meshheading:18230798-Methotrexate,
pubmed-meshheading:18230798-Middle Aged,
pubmed-meshheading:18230798-Multicenter Studies as Topic,
pubmed-meshheading:18230798-Predictive Value of Tests,
pubmed-meshheading:18230798-Prognosis,
pubmed-meshheading:18230798-Randomized Controlled Trials as Topic,
pubmed-meshheading:18230798-Retrospective Studies,
pubmed-meshheading:18230798-Tamoxifen,
pubmed-meshheading:18230798-Treatment Outcome,
pubmed-meshheading:18230798-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer.
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pubmed:affiliation |
Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan, Via Ripamoniti 435, Milan, Italy. giuseppe.viale@ieo.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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