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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-29
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pubmed:abstractText |
We have previously demonstrated that mRNA expression and enzyme activity levels of placental indoleamine 2,3-dioxygenase (IDO), which degrades L-tryptophan and blocks the proliferation of T cells, are significantly low in patients with severe pre-eclampsia. From this observation, we hypothesized that induction of maternal allogeneic immune reaction by reduced IDO activity is one of the causes of pre-eclampsia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1341-8076
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-6
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pubmed:meshHeading |
pubmed-meshheading:18226121-Animals,
pubmed-meshheading:18226121-Disease Models, Animal,
pubmed-meshheading:18226121-Enzyme Inhibitors,
pubmed-meshheading:18226121-Female,
pubmed-meshheading:18226121-Fetus,
pubmed-meshheading:18226121-Humans,
pubmed-meshheading:18226121-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:18226121-Male,
pubmed-meshheading:18226121-Mice,
pubmed-meshheading:18226121-Mice, Inbred BALB C,
pubmed-meshheading:18226121-Mice, Inbred C57BL,
pubmed-meshheading:18226121-Placenta,
pubmed-meshheading:18226121-Pre-Eclampsia,
pubmed-meshheading:18226121-Pregnancy,
pubmed-meshheading:18226121-Tryptophan
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pubmed:year |
2008
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pubmed:articleTitle |
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. nharuki@fujita-hu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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