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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6B
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pubmed:dateCreated |
2008-1-29
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pubmed:abstractText |
The outcome of advanced transitional cell carcinoma (TCC) is poor. Changes taking place in the tumor microenvironment are receiving increased scrutiny. Hypoxia is the key to increased expression of HIF-1alpha (hypoxia-inducible factor 1alpha) resulting in increased expression of growth factors (e.g. vascular endothelial growth factor (VEGF), epidermal growth factor (EGF)). The aim of our study was to establish an animal model with modulatable tumor hypoxia. Resulting tumor growth and growth factors were assessed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4225-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18225594-Animals,
pubmed-meshheading:18225594-Carcinoma, Transitional Cell,
pubmed-meshheading:18225594-Cell Hypoxia,
pubmed-meshheading:18225594-Disease Models, Animal,
pubmed-meshheading:18225594-Erythropoietin,
pubmed-meshheading:18225594-Hemoglobins,
pubmed-meshheading:18225594-Humans,
pubmed-meshheading:18225594-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:18225594-Immunohistochemistry,
pubmed-meshheading:18225594-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18225594-Male,
pubmed-meshheading:18225594-Oxygen,
pubmed-meshheading:18225594-Rats,
pubmed-meshheading:18225594-Rats, Wistar,
pubmed-meshheading:18225594-Recombinant Proteins,
pubmed-meshheading:18225594-Urinary Bladder Neoplasms,
pubmed-meshheading:18225594-Vascular Endothelial Growth Factor A
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pubmed:articleTitle |
Evaluation of hypoxia-mediated growth factors in a novel bladder cancer animal model.
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pubmed:affiliation |
Department of Urology, University of Bonn, D-53105 Bonn, Germany. guido.fechner@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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