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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-3-10
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pubmed:abstractText |
Currently, no consistently effective therapy is available to inhibit cell proliferation or metastasis of neuroendocrine tumor (NET) disease. The effects of 4 novel peptides were analyzed: a targeted cytotoxic analog of luteinizing hormone-releasing hormone (LH-RH) analog (AN-152), a targeted cytotoxic analog of somatostatin (AN-238), and 2 antagonists of growth hormone-releasing hormone (GH-RH) on 3 NET (carcinoid) cell lines that expressed respective peptide receptors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AN 238,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cytotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LHRH,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/T 107
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2008 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1404-14
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pubmed:meshHeading |
pubmed-meshheading:18224665-Apoptosis,
pubmed-meshheading:18224665-Bronchial Neoplasms,
pubmed-meshheading:18224665-Carcinoid Tumor,
pubmed-meshheading:18224665-Caspase 3,
pubmed-meshheading:18224665-Cell Cycle,
pubmed-meshheading:18224665-Cell Proliferation,
pubmed-meshheading:18224665-Cytotoxins,
pubmed-meshheading:18224665-Doxorubicin,
pubmed-meshheading:18224665-Flow Cytometry,
pubmed-meshheading:18224665-Gonadotropin-Releasing Hormone,
pubmed-meshheading:18224665-Growth Hormone-Releasing Hormone,
pubmed-meshheading:18224665-Humans,
pubmed-meshheading:18224665-Intestinal Neoplasms,
pubmed-meshheading:18224665-Intestine, Small,
pubmed-meshheading:18224665-Ki-67 Antigen,
pubmed-meshheading:18224665-Lung Neoplasms,
pubmed-meshheading:18224665-Pyrroles,
pubmed-meshheading:18224665-RNA, Messenger,
pubmed-meshheading:18224665-Receptors, LHRH,
pubmed-meshheading:18224665-Receptors, Somatostatin,
pubmed-meshheading:18224665-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18224665-Tumor Cells, Cultured
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors.
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pubmed:affiliation |
Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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