Linked Life Data

18223333

Source:http://linkedlifedata.com/resource/pubmed/id/18223333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-28
pubmed:abstractText
Herein, we describe the clinical, pathologic, immunohistochemical, and molecular features of 3 unique patients with long standing inflammatory bowel disease, all of whom developed numerous discrete hyperplastic/serrated colonic polyps similar to those described in the hyperplastic/serrated polyposis syndrome. The 3 patients (2 with ulcerative colitis and 1 with Crohn ileo-colitis) were evaluated for a variety of clinical, histologic (including the type, location and number of polyps in the colon), and immunohistochemical features [MLH-1, MSH-2, MGMT (O(6)-methylguanine-DNA methyltransferase), beta-catenin, and p53]. KRAS and BRAF mutation analysis was also performed on a subset of polyps from 2 patients. All patients had moderate-severe pancolitis of more than 10 years duration and had >20 colonic polyps. None had polyps in the upper gastrointestinal tract. Pathologically, a combination of conventional hyperplastic polyps and sessile serrated polyps (adenomas) were present in the 3 cases. In addition, serrated adenomas were present in 2 and conventional adenomas in 1. Two patients also had synchronous adenocarcinoma. All 3 cases showed retention of MLH-1 and MSH-2, and a membranous beta-catenin staining pattern. However, 2 cases showed loss of MGMT in several serrated polyps, and one also in adjacent colitic mucosa. KRAS mutations were detected in 5/11 serrated polyps. However, BRAF mutations were not present in any of the polyps tested. These findings suggest the possibility of a serrated pathway of carcinogenesis in inflammatory bowel disease characterized by silencing of MGMT, most likely by gene promoter methylation, KRAS mutations, and possibly other, as yet, uncharacterized molecular alterations, resulting eventually in progression to adenocarcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
296-303
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18223333-Adaptor Proteins, Signal Transducing, pubmed-meshheading:18223333-Adenocarcinoma, pubmed-meshheading:18223333-Adenomatous Polyps, pubmed-meshheading:18223333-Colonic Neoplasms, pubmed-meshheading:18223333-Colonic Polyps, pubmed-meshheading:18223333-Female, pubmed-meshheading:18223333-Humans, pubmed-meshheading:18223333-Hyperplasia, pubmed-meshheading:18223333-Inflammatory Bowel Diseases, pubmed-meshheading:18223333-Male, pubmed-meshheading:18223333-Middle Aged, pubmed-meshheading:18223333-Mutation, pubmed-meshheading:18223333-Neoplasm Proteins, pubmed-meshheading:18223333-Nuclear Proteins, pubmed-meshheading:18223333-Precancerous Conditions, pubmed-meshheading:18223333-Proto-Oncogene Proteins B-raf, pubmed-meshheading:18223333-Syndrome, pubmed-meshheading:18223333-Tumor Markers, Biological
pubmed:year
2008
pubmed:articleTitle
Hyperplastic/serrated polyposis in inflammatory bowel disease: a case series of a previously undescribed entity.
pubmed:affiliation
Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH-03755. Amitabh.Srivastava@Hitchcock.org
pubmed:publicationType
Journal Article, Case Reports