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rdf:type |
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lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0008633,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0185117,
umls-concept:C0279563,
umls-concept:C0334381,
umls-concept:C1414134,
umls-concept:C1422163,
umls-concept:C1517945,
umls-concept:C1520690,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-22
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pubmed:abstractText |
Loss of the chromosomal material at 16q is the most frequent genetic event in invasive and in situ (LCIS) lobular carcinoma of the breast. However, the smallest region of overlap at 16q is not restricted to just the CDH1 locus harbouring E-cadherin, suggesting that neighbouring genes might be involved in the development and progression of these tumours. Potential novel tumour suppressor genes (TSG) at 16q include CCCTC-binding factor (CTCF), Decreased Expression in Renal and Prostate Cancer (DERPC) and Dipeptidase 1 (DPEP1). The aim of this study is to assess the expression of these genes in LCIS and compare them with normal breast, using CDH1 as a control, in order to evaluate their role as TSGs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1573-7217
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-66
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pubmed:meshHeading |
pubmed-meshheading:18213475-Adult,
pubmed-meshheading:18213475-Aged,
pubmed-meshheading:18213475-Breast Neoplasms,
pubmed-meshheading:18213475-Carcinoma, Lobular,
pubmed-meshheading:18213475-Carcinoma in Situ,
pubmed-meshheading:18213475-Chromosome Deletion,
pubmed-meshheading:18213475-Chromosome Mapping,
pubmed-meshheading:18213475-Chromosomes, Human, Pair 16,
pubmed-meshheading:18213475-DNA Primers,
pubmed-meshheading:18213475-DNA-Binding Proteins,
pubmed-meshheading:18213475-Female,
pubmed-meshheading:18213475-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18213475-Humans,
pubmed-meshheading:18213475-Immunohistochemistry,
pubmed-meshheading:18213475-Middle Aged,
pubmed-meshheading:18213475-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18213475-RNA, Neoplasm,
pubmed-meshheading:18213475-RNA, Ribosomal, 18S,
pubmed-meshheading:18213475-Repressor Proteins,
pubmed-meshheading:18213475-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2009
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pubmed:articleTitle |
Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast.
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pubmed:affiliation |
Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK NG7 2UH. andrew.green@nottingham.ac.uk
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pubmed:publicationType |
Journal Article
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