Linked Life Data

18211833

Source:http://linkedlifedata.com/resource/pubmed/id/18211833

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-11
pubmed:abstractText
The TRAMP polyadenylation complexes have well-established functions in RNA surveillance, stimulating degradation by the 3' to 5' exonuclease activity of the exosome on a wide range of nuclear RNAs and RNA-protein complexes. Known targets include some of the non-protein coding RNA transcripts (ncRNAs), which are apparently widely transcribed from yeast and mammalian genomes. We will discuss potential mechanisms of TRAMP recruitment and exosome activation during RNA surveillance and degradation. Less well-understood observations link both the TRAMP and exosome complexes to chromatin structure and DNA repair, and we will speculate on the potential significance of these activities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
1779
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-46
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The nuclear RNA surveillance machinery: the link between ncRNAs and genome structure in budding yeast?
pubmed:affiliation
Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't