Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-2-11
pubmed:abstractText
Carbon nanotubes (CNTs) have been used in various fields as composites with other substances or alone to develop highly functional materials. CNTs hold great interest with respect to biomaterials, particularly those to be positioned in contact with bone such as prostheses for arthroplasty, plates or screws for fracture fixation, drug delivery systems, and scaffolding for bone regeneration. Accordingly, bone-tissue compatibility of CNTs and CNT influence on bone formation are important issues, but the effects of CNTs on bone have not been delineated. Here, it is found that multi-walled CNTs adjoining bone induce little local inflammatory reaction, show high bone-tissue compatibility, permit bone repair, become integrated into new bone, and accelerate bone formation stimulated by recombinant human bone morphogenetic protein-2 (rhBMP-2). This study provides an initial investigational basis for CNTs in biomaterials that are used adjacent to bone, including uses to promote bone regeneration. These findings should encourage development of clinical treatment modalities involving CNTs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1613-6829
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
240-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18205152-Animals, pubmed-meshheading:18205152-Biocompatible Materials, pubmed-meshheading:18205152-Bone Morphogenetic Protein 2, pubmed-meshheading:18205152-Bone Morphogenetic Proteins, pubmed-meshheading:18205152-Bone Regeneration, pubmed-meshheading:18205152-Durapatite, pubmed-meshheading:18205152-Graphite, pubmed-meshheading:18205152-Humans, pubmed-meshheading:18205152-Male, pubmed-meshheading:18205152-Materials Testing, pubmed-meshheading:18205152-Mice, pubmed-meshheading:18205152-Microscopy, Electron, Scanning, pubmed-meshheading:18205152-Nanotubes, Carbon, pubmed-meshheading:18205152-Osseointegration, pubmed-meshheading:18205152-Osteogenesis, pubmed-meshheading:18205152-Prostheses and Implants, pubmed-meshheading:18205152-Recombinant Proteins, pubmed-meshheading:18205152-Surface Properties, pubmed-meshheading:18205152-Transforming Growth Factor beta, pubmed-meshheading:18205152-X-Ray Diffraction
pubmed:year
2008
pubmed:articleTitle
Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects.
pubmed:affiliation
Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto Nagano 390-8621, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't