Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5861
pubmed:dateCreated
2008-1-18
pubmed:abstractText
Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a monochorionic twin pair, one preleukemic and one with frank leukemia, we establish the lineal relationship between these "cancer-propagating" cells and the preleukemic cell in which the TEL-AML1 fusion first arises or has functional impact. Analysis of TEL-AML1-transduced cord blood cells suggests that TEL-AML1 functions as a first-hit mutation by endowing this preleukemic cell with altered self-renewal and survival properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
18
pubmed:volume
319
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
336-9
pubmed:meshHeading
pubmed-meshheading:18202291-Acute Disease, pubmed-meshheading:18202291-Animals, pubmed-meshheading:18202291-Antigens, CD19, pubmed-meshheading:18202291-Antigens, CD34, pubmed-meshheading:18202291-Antigens, CD38, pubmed-meshheading:18202291-Apoptosis, pubmed-meshheading:18202291-Bone Marrow Transplantation, pubmed-meshheading:18202291-Child, Preschool, pubmed-meshheading:18202291-Core Binding Factor Alpha 2 Subunit, pubmed-meshheading:18202291-Diseases in Twins, pubmed-meshheading:18202291-Female, pubmed-meshheading:18202291-Fetal Blood, pubmed-meshheading:18202291-Gene Rearrangement, B-Lymphocyte, Heavy Chain, pubmed-meshheading:18202291-Humans, pubmed-meshheading:18202291-Male, pubmed-meshheading:18202291-Mice, pubmed-meshheading:18202291-Mice, Inbred NOD, pubmed-meshheading:18202291-Mice, SCID, pubmed-meshheading:18202291-Neoplasm Transplantation, pubmed-meshheading:18202291-Neoplastic Stem Cells, pubmed-meshheading:18202291-Oncogene Proteins, Fusion, pubmed-meshheading:18202291-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:18202291-Precursor Cells, B-Lymphoid, pubmed-meshheading:18202291-Preleukemia, pubmed-meshheading:18202291-Recombination, Genetic, pubmed-meshheading:18202291-Transplantation, Heterologous, pubmed-meshheading:18202291-Twins, Monozygotic
pubmed:year
2008
pubmed:articleTitle
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.
pubmed:affiliation
Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Twin Study