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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-17
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pubmed:abstractText |
Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1055-9965
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pubmed:author |
pubmed-author:AdamiHans-OlovHO,
pubmed-author:AnderssonSwen-OlofSO,
pubmed-author:AndrénOveO,
pubmed-author:DemichelisFrancescaF,
pubmed-author:EisensteinAnna SAS,
pubmed-author:FallKatjaK,
pubmed-author:HolmbergLarsL,
pubmed-author:HuangWeiW,
pubmed-author:JohanssonJan-ErikJE,
pubmed-author:KantoffPhilip WPW,
pubmed-author:MucciLorelei ALA,
pubmed-author:PawitanYudiY,
pubmed-author:PernerSvenS,
pubmed-author:RubinMark AMA,
pubmed-author:StampferMeir JMJ,
pubmed-author:StarkJennifer RJR
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-51
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pubmed:meshHeading |
pubmed-meshheading:18199732-Aged,
pubmed-meshheading:18199732-Cohort Studies,
pubmed-meshheading:18199732-Gene Expression Profiling,
pubmed-meshheading:18199732-Humans,
pubmed-meshheading:18199732-Immunoenzyme Techniques,
pubmed-meshheading:18199732-Male,
pubmed-meshheading:18199732-Prostate-Specific Antigen,
pubmed-meshheading:18199732-Prostatic Neoplasms,
pubmed-meshheading:18199732-Survival Rate,
pubmed-meshheading:18199732-Tissue Array Analysis,
pubmed-meshheading:18199732-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort.
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pubmed:affiliation |
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. lmucci@hsph.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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