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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-16
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pubmed:abstractText |
Cellulose xanthate-metal-tetracycline complexes (MCX-metal-Tc) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose was chemically modified to cellulose xanthate (MCX). The amount of metal bound to MCX was 0.36 mmol Cu(II)/g MCX and 0.26 mmol Zn(II)/g MCX. Tetracycline (Tc) bound to MCX-metal chelates was 0.08 mmol/g MCX-Cu(II) and 0.04 mmol/g MCX-Zn(II). The Tc release from MCX-metal-Tc was greatly sustained compared with that from a mixture of cellulose/metal/Tc. Furthermore, MCX-metal-Tc manifested antibacterial activity that lasted for 7-22 days. These results suggest that MCX-metal-Tc is a polymeric antibacterial agent with prolonged antibacterial activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cellulose,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Delayed-Action Preparations,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Tetracycline,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthines,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/cellulose xanthate,
http://linkedlifedata.com/resource/pubmed/chemical/copper(II) nitrate,
http://linkedlifedata.com/resource/pubmed/chemical/microcrystalline cellulose,
http://linkedlifedata.com/resource/pubmed/chemical/zinc nitrate
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1071-7544
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-5
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pubmed:meshHeading |
pubmed-meshheading:18197521-Anti-Bacterial Agents,
pubmed-meshheading:18197521-Cellulose,
pubmed-meshheading:18197521-Chemistry, Pharmaceutical,
pubmed-meshheading:18197521-Copper,
pubmed-meshheading:18197521-Delayed-Action Preparations,
pubmed-meshheading:18197521-Drug Carriers,
pubmed-meshheading:18197521-Drug Compounding,
pubmed-meshheading:18197521-Enterobacter aerogenes,
pubmed-meshheading:18197521-Hydrogen-Ion Concentration,
pubmed-meshheading:18197521-Nitrates,
pubmed-meshheading:18197521-Solubility,
pubmed-meshheading:18197521-Staphylococcus aureus,
pubmed-meshheading:18197521-Tetracycline,
pubmed-meshheading:18197521-Time Factors,
pubmed-meshheading:18197521-Xanthines,
pubmed-meshheading:18197521-Zinc Compounds
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pubmed:year |
2008
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pubmed:articleTitle |
Evaluation of cellulose xanthate-metal-tetracycline complexes as a polymeric antibacterial agent with prolonged antibacterial activity.
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pubmed:affiliation |
Laboratory of Biomedicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea.
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pubmed:publicationType |
Journal Article
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