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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-12
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pubmed:abstractText |
S100B is an established marker of brain damage. Used in the context as a biochemical marker, S100B denotes a measurement of all S100 proteins, including at least one S100B monomer, i.e. the sum of the two dimers S100A1B and S100BB. Almost all published studies are based on this "sum concentration". However, the brain specificity of S100B has been questioned and increased serum levels have also been reported after trauma without head injury. Since the S100B monomer dominates in the brain, we hypothesised that the S100BB dimer should be better related to outcome after severe traumatic brain injury than S100A1B or the "sum concentration".
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0942-0940
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-7; discussion 227
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:18193148-Adolescent,
pubmed-meshheading:18193148-Adult,
pubmed-meshheading:18193148-Aged,
pubmed-meshheading:18193148-Aged, 80 and over,
pubmed-meshheading:18193148-Biological Markers,
pubmed-meshheading:18193148-Blood-Brain Barrier,
pubmed-meshheading:18193148-Brain,
pubmed-meshheading:18193148-Brain Injuries,
pubmed-meshheading:18193148-Child,
pubmed-meshheading:18193148-Dimerization,
pubmed-meshheading:18193148-Female,
pubmed-meshheading:18193148-Glasgow Outcome Scale,
pubmed-meshheading:18193148-Humans,
pubmed-meshheading:18193148-Male,
pubmed-meshheading:18193148-Middle Aged,
pubmed-meshheading:18193148-Nerve Growth Factors,
pubmed-meshheading:18193148-Predictive Value of Tests,
pubmed-meshheading:18193148-Protein Isoforms,
pubmed-meshheading:18193148-Protein Subunits,
pubmed-meshheading:18193148-S100 Proteins,
pubmed-meshheading:18193148-Survival Rate,
pubmed-meshheading:18193148-Trauma Severity Indices,
pubmed-meshheading:18193148-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Serum levels of S100B, S100A1B and S100BB are all related to outcome after severe traumatic brain injury.
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pubmed:affiliation |
Department of Neurology, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, University of Göteborg, Göteborg, Sweden. karin.nylen@neuro.gu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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