|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-1-14
|
|
pubmed:abstractText |
Ventricular remodeling in type 2 diabetes predisposes to fatal coronary heart disease. The proapoptotic forkhead class O transcription factor 3a (FOXO3a) and its modulator, the cardioprotective longevity factor and class III histone deacetylase Sirtuin1 (Sirt1), have been implicated in the regulation of the cardiomyocyte lifespan and hypertrophy.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0263-6352
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
334-44
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18192848-Animals,
pubmed-meshheading:18192848-Apoptosis,
pubmed-meshheading:18192848-Cardiomyopathy, Hypertrophic,
pubmed-meshheading:18192848-Diabetes Mellitus,
pubmed-meshheading:18192848-Disease Models, Animal,
pubmed-meshheading:18192848-Echocardiography,
pubmed-meshheading:18192848-Forkhead Transcription Factors,
pubmed-meshheading:18192848-Male,
pubmed-meshheading:18192848-Myocytes, Cardiac,
pubmed-meshheading:18192848-Rats,
pubmed-meshheading:18192848-Sirtuin 1,
pubmed-meshheading:18192848-Sirtuins
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat.
|
|
pubmed:affiliation |
Institute of Biomedicine, Pharmacology, University of Helsinki, Finland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
