|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0031727,
umls-concept:C0038477,
umls-concept:C0220781,
umls-concept:C0243077,
umls-concept:C1004514,
umls-concept:C1155874,
umls-concept:C1332753,
umls-concept:C1421500,
umls-concept:C1749467,
umls-concept:C1883254,
umls-concept:C2304069
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2008-2-5
|
|
pubmed:abstractText |
Pyrrolo[3,4-c]carbazoles bearing solubilising basic side chains at the 8-position retain potent Wee1 and Chk1 inhibitory properties in isolated enzyme assays, and evidence of G2/M checkpoint abrogation in several cellular assays. Co-crystal structure studies confirm that the primary binding to the Wee1 enzyme is as described previously, with the C-8 side chains residing in an area of bulk tolerance.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
929-33
|
|
pubmed:dateRevised |
2011-11-2
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
|
|
pubmed:affiliation |
Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
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|
pubmed:publicationType |
Journal Article
|
