Source:http://linkedlifedata.com/resource/pubmed/id/18178354
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
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| pubmed:dateCreated |
2008-4-14
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| pubmed:abstractText |
In the presented case three herbal aphrodisiacs (Libidfit, Satibo and Viamax) were investigated for the presence of regular pharmaceuticals against erectile dysfunction. However, high-performance liquid chromatography with diode array detection and mass spectrometry (HPLC-DAD-MS) and nuclear magnetic resonance (NMR) analyses revealed the presence of ingredients, having a molecular structure strongly resembling those of sildenafil (Viagra) and vardenafil (Levitra). The health risk posed by these analogous substances is high because they were found to be potent phosphodiesterase 5 (PDE5) inhibitors used in pharmacologically relevant quantities having no known safety profile. Based on structural and functional analogy these analogs represent a new class of designer drugs and should be taken off the market for being unapproved drug substances. In the Libidfit court case this was done successfully, setting a precedent.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1872-6283
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
20
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| pubmed:volume |
177
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
e25-7
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| pubmed:year |
2008
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| pubmed:articleTitle |
Designer drugs in herbal aphrodisiacs.
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| pubmed:affiliation |
RIVM-National Institute for Public Health and the Environment, P.O. Box 1, NL-3720 BA Bilthoven, The Netherlands.
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| pubmed:publicationType |
Journal Article
|