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rdf:type |
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lifeskim:mentions |
umls-concept:C0002871,
umls-concept:C0005283,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0441889,
umls-concept:C0596803,
umls-concept:C0966897,
umls-concept:C1519595,
umls-concept:C1521840,
umls-concept:C2587213,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-1
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pubmed:abstractText |
Thalassemia associates anemia and iron overload, two opposite stimuli regulating hepcidin gene expression. We characterized hepatic hepcidin expression in 10 thalassemia major and 13 thalassemia intermedia patients. Hepcidin mRNA levels were decreased in the thalassemia intermedia group which presented both lower hemoglobin and higher plasma soluble transferrin receptor levels. There was no relationship between hepcidin mRNA levels and those of genes controlling iron metabolism, including HFE, hemojuvelin, transferrin receptor-2 and ferroportin. These results underline the role of erythropoietic activity on hepcidin decrease in thalassemic patients and suggest that mRNA modulations of other studied genes do not have a significant impact.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Cation Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HFE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HFE2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin,
http://linkedlifedata.com/resource/pubmed/chemical/TFR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/hepcidin,
http://linkedlifedata.com/resource/pubmed/chemical/metal transporting protein 1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:AbgueguenEmmanuelleE,
pubmed-author:AngelucciEmanueleE,
pubmed-author:BrissotPierreP,
pubmed-author:CamberleinEmilieE,
pubmed-author:CianciulliPaoloP,
pubmed-author:DétivaudLénaïckL,
pubmed-author:LaiMaria ElianaME,
pubmed-author:LizziAnna RitaAR,
pubmed-author:LoréalOlivierO,
pubmed-author:SorrentinoFrancescoF,
pubmed-author:TroadecMarie-BérengèreMB,
pubmed-author:VacquerStefaniaS,
pubmed-author:ZanninelliGiulianaG
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pubmed:issnType |
Electronic
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18166793-Adult,
pubmed-meshheading:18166793-Aged,
pubmed-meshheading:18166793-Anemia,
pubmed-meshheading:18166793-Antimicrobial Cationic Peptides,
pubmed-meshheading:18166793-Cation Transport Proteins,
pubmed-meshheading:18166793-Female,
pubmed-meshheading:18166793-GPI-Linked Proteins,
pubmed-meshheading:18166793-Gene Expression Regulation,
pubmed-meshheading:18166793-Histocompatibility Antigens Class I,
pubmed-meshheading:18166793-Humans,
pubmed-meshheading:18166793-Iron,
pubmed-meshheading:18166793-Liver,
pubmed-meshheading:18166793-Male,
pubmed-meshheading:18166793-Membrane Proteins,
pubmed-meshheading:18166793-Middle Aged,
pubmed-meshheading:18166793-Receptors, Transferrin,
pubmed-meshheading:18166793-beta-Thalassemia
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pubmed:year |
2008
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pubmed:articleTitle |
Anemia in beta-thalassemia patients targets hepatic hepcidin transcript levels independently of iron metabolism genes controlling hepcidin expression.
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pubmed:affiliation |
Inserm U-522, IFR 140, University Hospital Pontchaillou, Rennes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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