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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-1
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pubmed:abstractText |
Prolyl and asparaginyl hydroxylases are key oxygen-sensing enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the hypoxia inducible factor 1 (HIF-1) and nuclear factor-kappaB (NF-kappaB). Knockout of either HIF-1 or (IKKbeta-dependent) NF-kappaB pathways in intestinal epithelial cells promotes inflammatory disease in murine models of colitis. Both HIF-1 and NF-kappaB pathways are repressed by the action of hydroxylases through the hydroxylation of key regulatory molecules.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-65
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pubmed:meshHeading |
pubmed-meshheading:18166353-Amino Acids, Dicarboxylic,
pubmed-meshheading:18166353-Animals,
pubmed-meshheading:18166353-Caco-2 Cells,
pubmed-meshheading:18166353-Cell Culture Techniques,
pubmed-meshheading:18166353-Colitis,
pubmed-meshheading:18166353-Disease Models, Animal,
pubmed-meshheading:18166353-Enzyme Inhibitors,
pubmed-meshheading:18166353-Female,
pubmed-meshheading:18166353-Humans,
pubmed-meshheading:18166353-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:18166353-Mice,
pubmed-meshheading:18166353-Mice, Inbred C57BL,
pubmed-meshheading:18166353-Mixed Function Oxygenases,
pubmed-meshheading:18166353-NF-kappa B
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pubmed:year |
2008
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pubmed:articleTitle |
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
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pubmed:affiliation |
UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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