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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-12-31
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pubmed:databankReference |
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pubmed:abstractText |
The potential role of polymorphisms in the pfcrt and pfmdr1 genes and in vitro susceptibility to amodiaquine and desethylamodiaquine were explored in 15 chloroquine-resistant Colombian Plasmodium falciparum isolates. Single nucleotide polymorphisms in the pfcrt gene, including a newly reported mutation (S334N), were seen in isolates with decreased susceptibility to amodiaquine and desethylamodiaquine. The lowest susceptibility found to amodiaquine was observed in an isolate carrying a pfcrt and pfmdr1 Dd2-like haplotype, whereas a pfcrt haplotype related to the 7G8 Brazilian strain was found in a Colombian isolate with the lowest susceptibility to desethylamodiaquine. This exploratory study suggests that polymorphisms in the pfcrt and pfmdr1 genes play a role in amodiaquine and desethylamodiaquine resistance and warrants further study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9637
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1034-8
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pubmed:meshHeading |
pubmed-meshheading:18165517-Amino Acid Sequence,
pubmed-meshheading:18165517-Amodiaquine,
pubmed-meshheading:18165517-Animals,
pubmed-meshheading:18165517-Antimalarials,
pubmed-meshheading:18165517-Base Sequence,
pubmed-meshheading:18165517-Colombia,
pubmed-meshheading:18165517-Drug Resistance,
pubmed-meshheading:18165517-Inhibitory Concentration 50,
pubmed-meshheading:18165517-Membrane Transport Proteins,
pubmed-meshheading:18165517-Molecular Sequence Data,
pubmed-meshheading:18165517-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:18165517-Parasitic Sensitivity Tests,
pubmed-meshheading:18165517-Plasmodium falciparum,
pubmed-meshheading:18165517-Polymorphism, Single Nucleotide,
pubmed-meshheading:18165517-Protozoan Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.
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pubmed:affiliation |
International Center for Medical Research and Training (CIDEIM), Cali, Valle, Colombia. difereg@cideim.org.co
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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