Linked Life Data

18164806

Source:http://linkedlifedata.com/resource/pubmed/id/18164806

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pubmed-article:18164806pubmed:abstractTextThe goal of this study was to enhance gene delivery and tumor cell transfection in vivo by using a combination of ultrasonication with complex nanoparticles consisting of two types of nanoparticles: PEI/DNA beta-gal plasmid with highly positive zeta-potential and air-filled poly (lactic-co-glycolic acid) (PLGA) particles (with negative zeta-potential) manufactured in our laboratory. The PLGA/PEI/DNA nanoparticles were a colloid with positive zeta-potential and injected i.v. in nude mice with DU145 human prostate tumors. We found that the combination of PLGA/PEI/DNA nanoparticles with ultrasonication substantially enhanced tumor cell transfection in vivo. The overexpression of beta-gal gene was evaluated histochemically and by Western blot analysis. At least an 8-fold increase of the cell transfection efficacy was obtained in irradiated tumors compared to non-irradiated controls, while little to no cell death was produced by ultrasonication.lld:pubmed
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pubmed-article:18164806pubmed:year2008lld:pubmed
pubmed-article:18164806pubmed:articleTitleComposition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo.lld:pubmed
pubmed-article:18164806pubmed:affiliationCenter for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX 77555, USA.lld:pubmed
pubmed-article:18164806pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18164806pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:18164806pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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