Linked Life Data

18158892

Source:http://linkedlifedata.com/resource/pubmed/id/18158892

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-12-26
pubmed:abstractText
Rhomboids were only discovered to be novel proteases in 2001, but progress on understanding this newest family of intramembrane proteases has been rapid. They are now the best characterized of these rather mysterious enzymes that cleave transmembrane domains within the lipid bilayer. In particular, the biochemical analysis of solubilized rhomboids and, most recently, a flurry of high-resolution crystal structures, have led to real insight into their enzymology. Long-standing questions about how it is possible for a water-requiring proteolytic reaction to occur in the lipid bilayer are now answered for the rhomboids. Intramembrane proteases, which control many medically important biological processes, have made the transition from rather heretical outsiders to novel enzymes that are becoming well understood.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1097-2765
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
930-40
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cutting proteins within lipid bilayers: rhomboid structure and mechanism.
pubmed:affiliation
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't