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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
Natural killer (NK) cells contribute to the initial nonspecific response to viral infection, and viruses exhibit a range of sensitivities to NK cells in vivo. We investigated the role of NK cells in infection of mice by mouse adenovirus type 1 (MAV-1) using antibody-mediated depletion and knockout mice. MAV-1 causes encephalomyelitis and replicates to highest levels in brains. NK cell-depleted mice infected with MAV-1 showed brain viral loads 8-20 days p.i. that were similar to wild-type control non-depleted mice. Mice genetically deficient for NK cells behaved similarly to wild-type control mice with respect to brain viral loads and survival. We conclude that NK cells are not required to control virus replication in the brains of MAV-1-infected mice.
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pubmed:grant |
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pubmed:commentsCorrections |
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18155121-9636361
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
373
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-70
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18155121-Adenoviridae,
pubmed-meshheading:18155121-Adenoviridae Infections,
pubmed-meshheading:18155121-Animals,
pubmed-meshheading:18155121-Brain,
pubmed-meshheading:18155121-Immunity, Innate,
pubmed-meshheading:18155121-Killer Cells, Natural,
pubmed-meshheading:18155121-Leukocyte Reduction Procedures,
pubmed-meshheading:18155121-Mice,
pubmed-meshheading:18155121-Mice, Inbred BALB C,
pubmed-meshheading:18155121-Mice, Inbred C57BL,
pubmed-meshheading:18155121-Mice, Knockout,
pubmed-meshheading:18155121-Viral Load,
pubmed-meshheading:18155121-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Mouse adenovirus type 1 infection of natural killer cell-deficient mice.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.
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pubmed:publicationType |
Journal Article
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