18086849

Source:http://linkedlifedata.com/resource/pubmed/id/18086849

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0031327, umls-concept:C0360390, umls-concept:C0441655, umls-concept:C1524059, umls-concept:C2919063
pubmed:issue	3
pubmed:dateCreated	2008-2-26
pubmed:abstractText	The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antitubercular Agents, http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Synthetase Complex..., http://linkedlifedata.com/resource/pubmed/chemical/Mycolic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Oleic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Stearoyl-CoA Desaturase
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0066-4804
pubmed:author	pubmed-author:BesraGurdyal SGS, pubmed-author:GratraudPaulP, pubmed-author:KremerLaurentL, pubmed-author:SuroliaAvadheshaA, pubmed-author:SuroliaNamitaN
pubmed:issnType	Print
pubmed:volume	52
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1162-6
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:18086849-Antitubercular Agents, pubmed-meshheading:18086849-Cell-Free System, pubmed-meshheading:18086849-Culture Media, pubmed-meshheading:18086849-Enzyme Inhibitors, pubmed-meshheading:18086849-Fatty Acid Synthetase Complex, Type II, pubmed-meshheading:18086849-Microbial Sensitivity Tests, pubmed-meshheading:18086849-Mycobacterium bovis, pubmed-meshheading:18086849-Mycolic Acids, pubmed-meshheading:18086849-Oleic Acid, pubmed-meshheading:18086849-Stearoyl-CoA Desaturase
pubmed:year	2008
pubmed:articleTitle	Antimycobacterial Activity and Mechanism of Action of NAS-91.
pubmed:affiliation	Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS, UMR 5235, case 107, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't