Linked Life Data

18085505

Source:http://linkedlifedata.com/resource/pubmed/id/18085505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-12-18
pubmed:abstractText
Tissue engineering scaffolds require a controlled pore size and structure to host tissue formation. Supercritical carbon dioxide (scCO2) processing may be used to form foamed scaffolds in which the escape of CO2 from a plasticized polymer melt generates gas bubbles that shape the developing pores. The process of forming these scaffolds involves a simultaneous change in phase in the CO2 and the polymer, resulting in rapid expansion of a surface area and changes in polymer rheological properties. Hence, the process is difficult to control with respect to the desired final pore size and structure. In this paper, we describe a detailed study of the effect of polymer chemical composition, molecular weight and processing parameters on final scaffold characteristics. The study focuses on poly(DL-lactic acid) (PDLLA) and poly(DL-lactic acid-co-glycolic acid) (PLGA) as polymer classes with potential application as controlled release scaffolds for growth factor delivery. Processing parameters under investigation were temperature (from 5 to 55 degrees C) and pressure (from 60 to 230 bar). A series of amorphous PDLLA and PLGA polymers with various molecular weights (from 13 KD to 96 KD) and/or chemical compositions (the mole percentage of glycolic acid in the polymers was 0, 15, 25, 35 and 50 respectively) were employed. The resulting scaffolds were characterised by optical microscopy, scanning electron microscopy (SEM), and micro X-ray computed tomography (microCT). This is the first detailed study on using these series polymers for scaffold formation by supercritical technique. This study has demonstrated that the pore size and structure of the supercritical PDLLA and PLGA scaffolds can be tailored by careful control of processing conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1473-2262
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-77
pubmed:meshHeading
pubmed-meshheading:18085505-Absorbable Implants, pubmed-meshheading:18085505-Biocompatible Materials, pubmed-meshheading:18085505-Chemistry, Organic, pubmed-meshheading:18085505-Delayed-Action Preparations, pubmed-meshheading:18085505-Drug Delivery Systems, pubmed-meshheading:18085505-Guided Tissue Regeneration, pubmed-meshheading:18085505-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:18085505-Lactic Acid, pubmed-meshheading:18085505-Materials Testing, pubmed-meshheading:18085505-Microscopy, Electron, Scanning, pubmed-meshheading:18085505-Polyglycolic Acid, pubmed-meshheading:18085505-Polymers, pubmed-meshheading:18085505-Porosity, pubmed-meshheading:18085505-Surface Properties, pubmed-meshheading:18085505-Tensile Strength, pubmed-meshheading:18085505-Tissue Engineering, pubmed-meshheading:18085505-Tissue Scaffolds
pubmed:year
2007
pubmed:articleTitle
Control of pore size and structure of tissue engineering scaffolds produced by supercritical fluid processing.
pubmed:affiliation
School of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't