Source:http://linkedlifedata.com/resource/pubmed/id/18082709
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2007-12-17
|
| pubmed:abstractText |
The most important diagnostic features of Hirschsprung's disease (HD) are the combination of aganglionosis and hypertrophic nerve bundles. Acetylcholinesterase staining is widely used for diagnosis of HD as it identifies hypertrophic nerves in both diagnostic and intraoperative biopsies. The main drawback of this method is in the identification of ganglia. It has been suggested that the combination of this method together with another histochemical marker would be a superior diagnostic tool. Hematoxylin and eosin is still the diagnostic measure of choice for identifying ganglia in many centers, although it presents a persistent diagnostic challenge for pathologists trying to rapidly and accurately interpret the frozen biopsies that guide intraoperative decision making.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1531-5037
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2067-70
|
| pubmed:meshHeading |
pubmed-meshheading:18082709-Anus, Imperforate,
pubmed-meshheading:18082709-Appendicitis,
pubmed-meshheading:18082709-Biopsy, Needle,
pubmed-meshheading:18082709-Child, Preschool,
pubmed-meshheading:18082709-Colitis, Ulcerative,
pubmed-meshheading:18082709-Female,
pubmed-meshheading:18082709-Ganglia,
pubmed-meshheading:18082709-Hirschsprung Disease,
pubmed-meshheading:18082709-Humans,
pubmed-meshheading:18082709-Immunohistochemistry,
pubmed-meshheading:18082709-Infant,
pubmed-meshheading:18082709-Intestinal Mucosa,
pubmed-meshheading:18082709-Intraoperative Care,
pubmed-meshheading:18082709-Male,
pubmed-meshheading:18082709-Reference Values,
pubmed-meshheading:18082709-Sampling Studies,
pubmed-meshheading:18082709-Sensitivity and Specificity,
pubmed-meshheading:18082709-Specimen Handling,
pubmed-meshheading:18082709-Time Factors,
pubmed-meshheading:18082709-Tissue Fixation
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Fast evaluation of intraoperative biopsies for ganglia in Hirschsprung's disease.
|
| pubmed:affiliation |
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. wstaines@uottawa.ca
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|