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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1992-5-21
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pubmed:abstractText |
Two experiments were conducted to study the uptake of beta-carotene in plasma, lipoproteins, and blood cells in pigs (50 to 55 kg; n = 40) after an i.m. injection of 0, 10, 20, or 40 mg of beta-carotene. Blood was sampled at 0, 3, 6, 12, 24, and 48 h postinjection. beta-Carotene was not detectable in plasma, lipoproteins, or blood cells of control pigs. However, concentrations of beta-carotene in plasma and lipoproteins increased in a dose-related manner in injected animals. Distribution of beta-carotene in the lipoproteins changed with time postinjection. The beta-carotene associated with very low density lipoproteins increased and that in low density lipoproteins decreased with time in treated pigs. Concentrations of beta-carotene in lymphocytes of treated pigs also increased within 3 h postinjection. The profile of beta-carotene in lymphocytes was different from that observed in plasma and lipoproteins. Carotene was not detectable in neutrophils and erythrocytes. Treatment did not alter concentrations of retinol or alpha-tocopherol in plasma, lipoproteins, or blood cells. Therefore, lymphocytes specifically take up beta-carotene, thereby suggesting a possible role of beta-carotene in this immune cell.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carotenoids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin A,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-8812
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4883-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1808184-Animals,
pubmed-meshheading:1808184-Blood Cells,
pubmed-meshheading:1808184-Carotenoids,
pubmed-meshheading:1808184-Dose-Response Relationship, Drug,
pubmed-meshheading:1808184-Erythrocytes,
pubmed-meshheading:1808184-Female,
pubmed-meshheading:1808184-Injections, Intramuscular,
pubmed-meshheading:1808184-Lipoproteins,
pubmed-meshheading:1808184-Lymphocytes,
pubmed-meshheading:1808184-Neutrophils,
pubmed-meshheading:1808184-Swine,
pubmed-meshheading:1808184-Vitamin A,
pubmed-meshheading:1808184-Vitamin E,
pubmed-meshheading:1808184-beta Carotene
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pubmed:year |
1991
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pubmed:articleTitle |
Kinetic characteristics of beta-carotene uptake after an injection of beta-carotene in pigs.
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pubmed:affiliation |
Dept. of Anim. Sci. Washington State University, Pullman 99164-6320.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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