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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-1-31
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pubmed:abstractText |
Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-10358757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-11234016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-11536166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-11606250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-12505527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-14504081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-14707061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-15070767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-15294952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-15604012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-15821739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-16262248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-16318689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-16565719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-17312110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-17409017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-17536787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-17646027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-17670834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-18006589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-2543925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-9469412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18077718-9482438
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:AchdoutHagitH,
pubmed-author:AltmeyerRalfR,
pubmed-author:Bar-IlanAhuvaA,
pubmed-author:BruzzoneRobertoR,
pubmed-author:DasM SMS,
pubmed-author:HershkovitzOrenO,
pubmed-author:HoJoanna WJW,
pubmed-author:KamYiu WingYW,
pubmed-author:KudelkoMateuszM,
pubmed-author:MandelboimMichalM,
pubmed-author:MandelboimOferO,
pubmed-author:NalBeatriceB,
pubmed-author:PeirisMalikM,
pubmed-author:PorgadorAngelA,
pubmed-author:ZilkaAlonA
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2028-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18077718-Cell Line,
pubmed-meshheading:18077718-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:18077718-Humans,
pubmed-meshheading:18077718-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:18077718-Killer Cells, Natural,
pubmed-meshheading:18077718-Natural Cytotoxicity Triggering Receptor 2,
pubmed-meshheading:18077718-Receptors, Immunologic,
pubmed-meshheading:18077718-Recombinant Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.
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pubmed:affiliation |
Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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