|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-2-4
|
|
pubmed:abstractText |
We have previously described the generation of reconstituting retroviral (ReCon) vectors designed for cancer gene therapy using cytotoxic gene products. The unique vector structure with a promoter physically separated from the transgene allows generation of stable virus producer cells irrespective of the toxic gene. The mechanism of synthesis of DNA from retroviral RNA dictates that infection leads to the reconstitution of functional expression cassettes in the target cell.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1099-498X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
113-22
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18076132-Animals,
pubmed-meshheading:18076132-Base Sequence,
pubmed-meshheading:18076132-Cell Death,
pubmed-meshheading:18076132-Cytotoxins,
pubmed-meshheading:18076132-Gene Therapy,
pubmed-meshheading:18076132-Genetic Engineering,
pubmed-meshheading:18076132-Genetic Vectors,
pubmed-meshheading:18076132-HeLa Cells,
pubmed-meshheading:18076132-Humans,
pubmed-meshheading:18076132-Mice,
pubmed-meshheading:18076132-Molecular Sequence Data,
pubmed-meshheading:18076132-NIH 3T3 Cells,
pubmed-meshheading:18076132-Neoplasms,
pubmed-meshheading:18076132-Organ Specificity,
pubmed-meshheading:18076132-Polyadenylation,
pubmed-meshheading:18076132-Promoter Regions, Genetic,
pubmed-meshheading:18076132-Retroviridae,
pubmed-meshheading:18076132-Sequence Deletion,
pubmed-meshheading:18076132-Transduction, Genetic
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Reconstituting retroviral (ReCon) vectors facilitating delivery of cytotoxic genes in cancer gene therapy approaches.
|
|
pubmed:affiliation |
Austrianova Biotechnology GmbH, Vienna, Austria.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
