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pubmed:abstractText |
The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly identified antiapoptotic proteins comprising the BI-1 family, namely Bax-inhibitory Protein-1 (BI-1), Lifeguard (LFG), and h-GAAP. In a search for vertebrate proteins presumably belonging to the BI-1 family, we found that Growth-hormone inducible transmembrane protein (Ghitm) is another prospective member of the BI-1 family. Here we characterise Ghitm in a first analysis regarding its phylogeny, expression in cancer cell lines, and proteomical properties.
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pubmed:affiliation |
Department for Plastic, Hand, Reconstructive Surgery, Medical School Hannover, Podbielskistrasse 380, D-30659 Hannover, Germany. reimers.kerstin@mh-hannover.de
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