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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-3
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pubmed:abstractText |
Adenylyl cyclases (ACs) are a family of effector molecules for G-protein-coupled receptors. The 2 ACs most abundantly expressed in cardiac myocytes are types 5 (AC5) and 6 (AC6), which have 65% amino acid homology. It has been speculated that coexpression of 2 AC types in cardiac myocytes represents redundancy, but the specific role of AC6 in cardiac physiology and its differences from AC5 remain to be defined.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-9
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:18071070-Adenylate Cyclase,
pubmed-meshheading:18071070-Animals,
pubmed-meshheading:18071070-Calcium,
pubmed-meshheading:18071070-Cyclic AMP,
pubmed-meshheading:18071070-Diastole,
pubmed-meshheading:18071070-Gene Deletion,
pubmed-meshheading:18071070-Mice,
pubmed-meshheading:18071070-Mice, Knockout,
pubmed-meshheading:18071070-Mice, Transgenic,
pubmed-meshheading:18071070-Myocardial Contraction,
pubmed-meshheading:18071070-Myocytes, Cardiac,
pubmed-meshheading:18071070-Receptors, Adrenergic, beta,
pubmed-meshheading:18071070-Ventricular Dysfunction, Left
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pubmed:year |
2008
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pubmed:articleTitle |
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.
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pubmed:affiliation |
Department of Medicine, University of California, San Diego, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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