Source:http://linkedlifedata.com/resource/pubmed/id/18069417
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2007-12-11
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pubmed:abstractText |
The chemokine Monocyte Chemoattractant Protein (MCP)-1/CCL2, a chemoattractant for mononuclear cells, has already been implicated in the pathogenesis of sarcoidosis. A single nucleotide polymorphism (SNP) located at the position -2518 (A to G) of the MCP-1 gene has been reported to alter production of the MCP-1 protein in vitro and ex vivo. The present study, therefore, explored a possible association between MCP-1-2518 SNP and pulmonary sarcoidosis including its clinical subtypes, especially Löfgren's syndrome (LS). Relationship between MCP-1-2518 SNP and serum MCP-1 levels was also investigated.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1124-0490
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-8
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pubmed:meshHeading |
pubmed-meshheading:18069417-Adult,
pubmed-meshheading:18069417-Alleles,
pubmed-meshheading:18069417-Case-Control Studies,
pubmed-meshheading:18069417-Chemokine CCL2,
pubmed-meshheading:18069417-Czech Republic,
pubmed-meshheading:18069417-Female,
pubmed-meshheading:18069417-Genetic Predisposition to Disease,
pubmed-meshheading:18069417-Genotype,
pubmed-meshheading:18069417-Humans,
pubmed-meshheading:18069417-Male,
pubmed-meshheading:18069417-Middle Aged,
pubmed-meshheading:18069417-Polymorphism, Single Nucleotide,
pubmed-meshheading:18069417-Sarcoidosis, Pulmonary,
pubmed-meshheading:18069417-Syndrome
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pubmed:year |
2007
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pubmed:articleTitle |
The MCP-1-2518 (A to G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis: association with Löfgren's syndrome.
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pubmed:affiliation |
Palacky University Olomouc, Czech Republic.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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