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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1992-5-1
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pubmed:abstractText |
Almitrine bismesylate, a chemoreceptor agonist, improves hypoxaemia in a high percentage of chronic obstructive pulmonary disease (COPD) patients and its long-term use may thus be of interest in these patients. The course of pulmonary haemodynamics during a one year treatment was investigated in severe COPD patients (forced expiratory volume in one second FEV1 = 1,040 +/- 80 SEM ml) with persistent hypoxaemia (initial arterial oxygen tension (PaO2) in the range 6.6-8.6 kPa (50-65 mmHg]. Patients were given either almitrine (A, n = 27), 100 mg.day-1, during two consecutive months per quarter followed by a one month wash-out period (intermittent "schedule"), or placebo (P, n = 18) with the same schedule. Eleven patients in group A and 8 in group P could not complete the one year study because of lack of compliance, worsening of respiratory insufficiency, or for other reasons. In the remaining patients, PaO2 significantly increased in group A (n = 16) from 7.6 +/- 0.1 to 8.3 +/- 0.2 kPa (56.9 +/- 1.0 to 62.7 +/- 1.7 mmHg) (p less than 0.001) but not in group P (n = 10) from 7.5 +/- 0.3 to 7.9 +/- 0.3 kPa (56.1 +/- 2.3 to 59.1 +/- 2.1 mmHg). PaCO2 did not significantly change in either group. Pulmonary artery mean pressure (PAP) was stable in both groups: from 26.8 +/- 2.1 to 25.4 +/- 1.9 mmHg in group A, and from 20.6 +/- 1.1 to 20.9 +/- 1.5 mmHg in group P.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0903-1936
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1215-22
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1804669-Adult,
pubmed-meshheading:1804669-Aged,
pubmed-meshheading:1804669-Almitrine,
pubmed-meshheading:1804669-Anoxia,
pubmed-meshheading:1804669-Blood Pressure,
pubmed-meshheading:1804669-Cardiac Output,
pubmed-meshheading:1804669-Double-Blind Method,
pubmed-meshheading:1804669-Humans,
pubmed-meshheading:1804669-Lung Diseases, Obstructive,
pubmed-meshheading:1804669-Middle Aged,
pubmed-meshheading:1804669-Oxygen,
pubmed-meshheading:1804669-Pulmonary Artery,
pubmed-meshheading:1804669-Respiratory Mechanics,
pubmed-meshheading:1804669-Time Factors,
pubmed-meshheading:1804669-Vascular Resistance
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pubmed:year |
1991
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pubmed:articleTitle |
One year treatment with almitrine improves hypoxaemia but does not increase pulmonary artery pressure in COPD patients.
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pubmed:affiliation |
Hôpital Universitaire, Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
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