Linked Life Data

18043513

Source:http://linkedlifedata.com/resource/pubmed/id/18043513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-22
pubmed:abstractText
Stem and progenitor cells derived from adult marrow have been shown to regenerate vascular cells in response to injury. However, it is unclear whether the type of injury dictates the contribution of such cells to neovascularization and which subpopulations of cells contribute to vascular regeneration. To address these questions, we determined the extent that hematopoietic stem cells (HSC) contributed to blood vessel formation in response to two types of liver injury, partial hepatectomy (PH) and toxin-induced injury. Lac-Z-labeled HSC were engrafted into lethally irradiated, genetically matched recipients. After 14 d, we identified transplanted cells engrafted within the vascular endothelium of toxin-damaged liver, but not in the vasculature of liver regenerated in response to PH. Engraftment of HSC-derived cells occurred in a gradient fashion with the highest activity in the severely injured areas. Although HSC-derived cells contributed to both microvessels and large vessels, the large caliber vessels trended toward higher engraftment levels. Thus, the contribution of marrow-derived cells to hepatic neovascularization is dependent upon the type of injury sustained. Furthermore, following toxin-induced liver injury, engraftment rates trended higher in large vessels compared with capillaries, suggesting that remodeling of existing vessels is a predominant mechanism of repair, relative to the formation of new microvasculature.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Injury mechanism dictates contribution of bone marrow-derived cells to murine hepatic vascular regeneration.
pubmed:affiliation
Department of Pediatrics, Division of Neonatology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA. kirstena@bcm.tmc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural