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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-1-25
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pubmed:abstractText |
Polymorphisms in the genes coding folate-metabolizing enzymes affect the risk of some forms of cancer. We investigated the association between these polymorphisms and non-Hodgkin lymphoma (NHL) risk in a population-based study (583 cases and 1700 controls). The MTHFR 677TT and CT genotypes were associated with reduced risk for NHL [odds ratios (OR) = 0.79; 95% confidence intervals (CI) = 0.65-0.98 for 677CT and 0.61; 0.45-0.82 for 677TT] and diffuse large B-cell lymphoma (DLBCL) (OR = 0.68; 0.51-0.88 for 677CT; OR = 0.56; 0.38-0.83 for 677TT). The MTHFR 1298CC genotype was associated with increased risk for NHL (OR = 1.71; 1.07-2.75) and T-cell lymphoma (OR = 3.05; 1.53-6.11). The MTRR 66GG genotype was associated with increased risk for DLBCL (OR = 1.56; 1.03-2.38) and the TYMS 2R2R genotype was associated with increased risk for T-cell lymphoma (OR = 2.83; 1.33-6.01). Using subjects with 3RG3RG as a reference group, TYMS 2R2R was associated with increased risk for T-cell lymphoma (OR = 2.46; 1.04-5.79). Interestingly, we observed a reduced association between the TYMS 2R3RG genotype and DLBCL (OR = 0.61; 0.38-0.99). These results suggest that MTHFR, MTRR and TYMS polymorphisms may play a significant role in the risk for NHL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1365-2141
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pubmed:author |
pubmed-author:ChoiJin-SuJS,
pubmed-author:KimHee NamHN,
pubmed-author:KimHyeoung-JoonHJ,
pubmed-author:KimYeo-KyeoungYK,
pubmed-author:LeeIl-KwonIK,
pubmed-author:LeeJe-JungJJ,
pubmed-author:ParkKyeong-SooKS,
pubmed-author:ShinMin-HoMH,
pubmed-author:ShinMyung-GeunMG,
pubmed-author:TranHuong Thi ThanhHT,
pubmed-author:YangDeok-HwanDH
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-94
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pubmed:meshHeading |
pubmed-meshheading:18042267-Adolescent,
pubmed-meshheading:18042267-Adult,
pubmed-meshheading:18042267-Aged,
pubmed-meshheading:18042267-Aged, 80 and over,
pubmed-meshheading:18042267-Case-Control Studies,
pubmed-meshheading:18042267-Female,
pubmed-meshheading:18042267-Ferredoxin-NADP Reductase,
pubmed-meshheading:18042267-Folic Acid,
pubmed-meshheading:18042267-Gene Frequency,
pubmed-meshheading:18042267-Genetic Predisposition to Disease,
pubmed-meshheading:18042267-Genotype,
pubmed-meshheading:18042267-Haplotypes,
pubmed-meshheading:18042267-Humans,
pubmed-meshheading:18042267-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:18042267-Lymphoma, Non-Hodgkin,
pubmed-meshheading:18042267-Lymphoma, T-Cell,
pubmed-meshheading:18042267-Male,
pubmed-meshheading:18042267-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:18042267-Middle Aged,
pubmed-meshheading:18042267-Odds Ratio,
pubmed-meshheading:18042267-Polymorphism, Genetic,
pubmed-meshheading:18042267-Risk,
pubmed-meshheading:18042267-Thymidylate Synthase
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pubmed:year |
2008
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pubmed:articleTitle |
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma.
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pubmed:affiliation |
Genome Research Centre for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Jeollanamdo, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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