Source:http://linkedlifedata.com/resource/pubmed/id/18039121
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2007-11-27
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pubmed:abstractText |
Loss of Ca(2+) homeostasis, often in the form of cytoplasmic increases, leads to cell injury. Depending upon cell type and the intensity of Ca(2+) toxicity, the ensuing pathology can be reversible or irreversible. Although multiple destructive processes are activated by Ca(2+), lethal outcomes are determined largely by Ca(2+)-induced mitochondrial permeability transition. This form of damage is primarily dependent upon mitochondrial Ca(2+) accumulation, which is regulated by the mitochondrial membrane potential. Retention of the mitochondrial membrane potential during Ca(2+) increases favors mitochondrial Ca(2+) uptake and overload, resulting in mitochondrial permeability transition and cell death. In contrast, dissipation of mitochondrial membrane potential reduces mitochondrial Ca(2+) uptake, retards mitochondrial permeability transition, and delays death, even in cells with large Ca(2+) increases. The rates of mitochondrial membrane potential dissipation and mitochondrial Ca(2+) uptake may determine cellular sensitivity to Ca(2+) toxicity under pathological conditions, including ischemic injury.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1553-4006
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-34
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pubmed:meshHeading |
pubmed-meshheading:18039121-Animals,
pubmed-meshheading:18039121-Apoptosis,
pubmed-meshheading:18039121-Calcium,
pubmed-meshheading:18039121-Homeostasis,
pubmed-meshheading:18039121-Humans,
pubmed-meshheading:18039121-Membrane Potential, Mitochondrial,
pubmed-meshheading:18039121-Mitochondria,
pubmed-meshheading:18039121-Myocardial Reperfusion Injury,
pubmed-meshheading:18039121-Permeability
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pubmed:year |
2006
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pubmed:articleTitle |
Calcium in cell injury and death.
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pubmed:affiliation |
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA. zdong@mcg.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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