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pubmed-article:18035413pubmed:abstractTextWe investigated the prognostic significance of genetic polymorphism for glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1) in 254 Chinese patients with de novo acute myeloid leukemia (AML) other than AML-M3. The early death rate after the initiation of chemotherapy was similar between the GSTT1+/GSTM1+ group and GSTT1-/GSTM1- group. The complete remission (CR) rate was higher in GSTM1+ group than in GSTM1- group (OR=1.88; P=0.03) after the first course of chemotherapy, and was higher in GSTT1+ group than in GSTT1- group (OR=2.20; P=0.02) after the second course of chemotherapy. Overall survival and disease-free survival of CR patients in GSTT1 and GSTM1 double present group was better than in GSTT1- and/or GSTM1-group (P=0.03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients.lld:pubmed
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pubmed-article:18035413pubmed:authorpubmed-author:WangJianxiang...lld:pubmed
pubmed-article:18035413pubmed:authorpubmed-author:YangLinLlld:pubmed
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pubmed-article:18035413pubmed:authorpubmed-author:LiuLiangLlld:pubmed
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pubmed-article:18035413pubmed:articleTitleGlutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia.lld:pubmed
pubmed-article:18035413pubmed:affiliationState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. zjxiao@hotmail.comlld:pubmed
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