Linked Life Data

18035413

Source:http://linkedlifedata.com/resource/pubmed/id/18035413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-5-7
pubmed:abstractText
We investigated the prognostic significance of genetic polymorphism for glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1) in 254 Chinese patients with de novo acute myeloid leukemia (AML) other than AML-M3. The early death rate after the initiation of chemotherapy was similar between the GSTT1+/GSTM1+ group and GSTT1-/GSTM1- group. The complete remission (CR) rate was higher in GSTM1+ group than in GSTM1- group (OR=1.88; P=0.03) after the first course of chemotherapy, and was higher in GSTT1+ group than in GSTT1- group (OR=2.20; P=0.02) after the second course of chemotherapy. Overall survival and disease-free survival of CR patients in GSTT1 and GSTM1 double present group was better than in GSTT1- and/or GSTM1-group (P=0.03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0145-2126
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1288-91
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia.
pubmed:affiliation
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. zjxiao@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't